Nanosynt is an efficient and extremely safe synthetic bone substitute. It is manufactured  with high-purity pharmaceutical raw materials and undergoes temperatures above 1000°C. Besides, the production is in accordance to rigid international standards, which eliminates contamination risks.

Nanosynt granules observed under a scanning electron microscope (20x). Note its characteristic texture (100x). Source: Prof. Me. Leonel Oliveria

 

Although its chemical formula is similar to other products available in the market, 60% of hydroxyapatite + 40% of B-TCP, its surprising cellular interaction has come to fulfill a need of many professionals, since it shortens the restorative process. That significant advancement happens, mainly, because of two intrinsic characteristics of the FGM biomaterial: ultra-porous structure and exceptional hydrophilicity.

The evidence of the trabecular structure of the granules (4,000x and 20,000x, respectively), contributes to the understanding of the concepts of ultra-porosity and high hydrophilicity, intrinsic to the FGM biomaterial. Source: Prof. Me. Leonel Oliveria.

The benefits promoted by the ultra-porous superficial pattern are mostly associated with cellular adhesion. That is because this type of constitution creates the perfect conditions for adhesion (accommodation and fixation) and consequent osteoconduction for the deposition of the new matrix. The aspect of irregular interlinked trabecula configures a perfect environment for osteoblast anchoring and stabilization, contributing to the shortening of the restorative response.

Photomicrography of the particle of the Nanosynt biomaterial and the osteoblast cell in intimate contact. Source: Profa. Dra Vânia Coutinho (CERTBIO/ LAMMEa-UFCG-PB) 2017

For professionals who use biological agents (such as the tridimensional leukoplakia fibrin matrix), the interaction happens in an even more appropriate manner, since the fibrin web contributes to the adhesion, initial hemostatic stability and autologous tissue mimetic.

After the centrifugation and preparation of the autologous blood aggregates, it is possible to associate them to synthetic materials. Their surface helps both the retention of the fibrin web (2) as well as the stabilization promoted by the L-PRF membranes (3). Source: Prof. Me. Leonel Oliveria

 

On the other hand, the excellent hydrophilicity grants it extraordinary wettability. That characteristic is particularly desired because it allows the blood, source of mediators and undifferentiated cells, to enter the biomaterial granules and make it possible for new ossification centers to develop, since nutrition, as a whole, is optimized in permeable environments. That behavior helps in the understanding of the superiority of Nanosynt when compared to other market references.

Besides the synergy promoted for the restoration, other advantages related to synthetic biomaterials can still be pointed out: lower patient morbidity, unlimited volume, easy handling and accommodation in the defect, low cost and, certainly, effectiveness in bone substitution.

 

Source: Elora Casett